Study Report
Study Information
Basic Info
| Reference |
Bruenig, D.,2017(a) PMID: 28160694
|
| Citation |
Bruenig, D., et al. (2017). "Genetic and serum biomarker evidence for a relationship between TNFalpha and PTSD in Vietnam war combat veterans." Compr Psychiatry 74: 125-133. |
| Phenotype |
PTSD severity |
| Trauma |
Vietnam combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study |
| Sample Size |
159 cases, 140 controls |
| SNP/Marker Size |
1 SNP |
| Predominant Ethnicity |
Caucasian |
| Population |
Australian |
| Gender |
Not mentioned |
| Age |
Case: mean age=68.47 years,SD=4.16, Control: mean age=69.13 years,SD=4.14 |
Detail Info
| Sample Diagnosis |
DSM-5 |
| Related Diagnostic Tools |
Clinician Administered PTSD Scale for DSM 5 (CAPS), The Connor-Davidson Resilience Scale (CD RISC), Mini International Neuropsychiatric Interview DSM IV (MINI) |
| Sample Status |
23 with Major depression, 33 with Suicide risk, 39 with Agoraphobia, 8 with Social phobia, 28 with Alcohol dependence, 5 with Alcohol abuse, 15 with Generalised anxiety disorder |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
The polymorphism rs1800629 was associated with PTSD severity. GG is a risk genotype for PTSD in Caucasian cohorts. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs1800629
|
CAPS score |
TNF |
ANOVA: F(2,280)=3.314, P-value=0.038. Post-hoc comparation: AA/AG vs GG: P-value=0.045. |
The GG genotype showing significantly higher CAPS scores tha......
The GG genotype showing significantly higher CAPS scores than the pooled AA/AG genotype.
More...
|
Significant |
