Study Report
Study Information
Basic Info
| Reference |
Kilaru, V.,2016 PMID: 27219346
|
| Citation |
Kilaru, V., et al. (2016). "Genome-wide gene-based analysis suggests an association between Neuroligin 1 (NLGN1) and post-traumatic stress disorder." Transl Psychiatry 6: e820. |
| Phenotype |
Current PTSD diagnosis |
| Trauma |
Various |
| Study Design |
Cross-sectional study |
| Study Type |
Genome-wide association study |
| Sample Size |
1158 cases, 2520 controls |
| SNP/Marker Size |
GTP: 634,854 variants. DCHS: 273,846 variants. |
| Predominant Ethnicity |
Black |
| Population |
American |
| Gender |
GTP: 30% males, 70% females. DCHS: 100% females. |
| Age |
GTP: mean age=40 years, SD=13. DCHS: mean age=26.4 years, SD=5.6. |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
The modified PTSD Symptom Scale (PSS),Mini International Neuropsychiatric Interview (MINI) |
| Sample Status |
The PTSD cases in our analysis had current PTSD symptoms while the controls did not. Both the cases and controls had been exposed to at least one traumatic life experience. |
| Controls Exposed |
NS |
| Replication Size |
134 cases, 246 controls |
| Result Summary |
We identified two genes (NLGN1 and ZNRD1-AS1) that associate with PTSD after multiple test correction. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 2)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs6779753
|
PTSD diagnosis |
NLGN1 |
In the GTP cohort: P-value<0.05 after after Bonferroni correction. In the DCHS cohort: t=0.28, P-value=0.78. |
For the GTP cohort, the SNP with the lowest P-value in NLGN1......
For the GTP cohort, the SNP with the lowest P-value in NLGN1 was rs6779753. However, for DCHS, the SNP rs6779753 did not associate.
More...
|
Significant |
|
rs4894661
|
PTSD diagnosis |
NLGN1 |
In the DCHS cohort: P-value=0.021. |
For DCHS, the SNP most associated with PTSD was rs4894661.
For DCHS, the SNP most associated with PTSD was rs4894661.
|
Significant |
