Gene Report

Basic Info

Approved Symbol	NLGN1
Symbol Alias	KIAA1070
Approved Name	neuroligin 1
Location	3q26.32
Position	chr3:173396284-174286644, 1
External Links	HGNC: 14291 Entrez Gene: 22871 Ensembl: ENSG00000169760 UCSC: uc003fio.2
No. of Association Results	1 (Positive: 1; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Kilaru, V.,2016	PTSD diagnosis	rs6779753 ; rs4894661	Significant

Gene functional annotation

Gene related GO terms (count: 68)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0097104	postsynaptic membrane assembly	biological process	IBA; ISS	1
GO:0009897	external side of plasma membrane	cellular component	IEA	9
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	biological process	ISS	1
GO:0097114	NMDA glutamate receptor clustering	biological process	ISS	2
GO:0097110	scaffold protein binding	molecular function	IDA[17474715]	2
GO:2000302	positive regulation of synaptic vesicle exocytosis	biological process	ISS	1
GO:1902533	positive regulation of intracellular signal transduction	biological process	ISS	1
GO:2000463	positive regulation of excitatory postsynaptic potential	biological process	IGI[23143522]; ISS	4
GO:1900029	positive regulation of ruffle assembly	biological process	ISS	2
GO:0005794	Golgi apparatus	cellular component	ISS	17
GO:0046983	protein dimerization activity	molecular function	ISS	5
GO:0051260	protein homooligomerization	biological process	ISS	3
GO:0045184	establishment of protein localization	biological process	ISS	2
GO:0052689	carboxylic ester hydrolase activity	molecular function	IBA	2
GO:0017146	NMDA selective glutamate receptor complex	cellular component	IEA	5
GO:0043197	dendritic spine	cellular component	ISS	9
GO:0004872	receptor activity	molecular function	IBA; ISS	4
GO:0032433	filopodium tip	cellular component	ISS	1
GO:0042043	neurexin family protein binding	molecular function	IBA; ISS	1
GO:0097105	presynaptic membrane assembly	biological process	IBA; ISS	1
GO:0097119	postsynaptic density protein 95 clustering	biological process	ISS	1
GO:0006605	protein targeting	biological process	ISS	1
GO:0098793	presynapse	cellular component	IEA; ISS	3
GO:0051965	positive regulation of synapse assembly	biological process	IDA[24613359]; ISS	6
GO:0035418	protein localization to synapse	biological process	ISS	1
GO:0043198	dendritic shaft	cellular component	IEA	3
GO:2000809	positive regulation of synaptic vesicle clustering	biological process	IEA	1
GO:0051290	protein heterotetramerization	biological process	IEA	1
GO:0097120	receptor localization to synapse	biological process	ISS	1
GO:0030165	PDZ domain binding	molecular function	IDA[17474715]	4
GO:0023041	neuronal signal transduction	biological process	TAS[15797875]	1
GO:0061002	negative regulation of dendritic spine morphogenesis	biological process	IGI[23143522]	1
GO:0097091	synaptic vesicle clustering	biological process	ISS	1
GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness	biological process	ISS	1
GO:0045664	regulation of neuron differentiation	biological process	ISS	1
GO:0051491	positive regulation of filopodium assembly	biological process	ISS	1
GO:0050839	cell adhesion molecule binding	molecular function	ISS	2
GO:0072553	terminal button organization	biological process	ISS	1
GO:0097481	neuronal postsynaptic density	cellular component	TAS[15797875]	4
GO:0048511	rhythmic process	biological process	IEA	3
GO:0030054	cell junction	cellular component	IEA	24
GO:0002087	regulation of respiratory gaseous exchange by neurological system process	biological process	IEA	1
GO:0009986	cell surface	cellular component	IBA; ISS	21
GO:0007399	nervous system development	biological process	ISS	7
GO:0045202	synapse	cellular component	ISS	7
GO:1900244	positive regulation of synaptic vesicle endocytosis	biological process	ISS	1
GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	biological process	ISS	2
GO:0030425	dendrite	cellular component	ISS	19
GO:1902474	positive regulation of protein localization to synapse	biological process	IEA	1
GO:0014069	postsynaptic density	cellular component	ISS	11
GO:0031175	neuron projection development	biological process	IDA[22750515]	8
GO:0048488	synaptic vesicle endocytosis	biological process	IBA	1
GO:0005886	plasma membrane	cellular component	ISS	99
GO:0097115	neurexin clustering involved in presynaptic membrane assembly	biological process	ISS	1
GO:0032230	positive regulation of synaptic transmission, GABAergic	biological process	ISS	2
GO:0005615	extracellular space	cellular component	IBA	27
GO:0005887	integral component of plasma membrane	cellular component	IBA; ISS	36
GO:0048789	cytoskeletal matrix organization at active zone	biological process	ISS	1
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	ISS	4
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	biological process	IGI[23143522]; ISS	3
GO:0060291	long-term synaptic potentiation	biological process	IEA	5
GO:0060999	positive regulation of dendritic spine development	biological process	IGI[23143522]; ISS	2
GO:0016080	synaptic vesicle targeting	biological process	ISS	1
GO:0007416	synapse assembly	biological process	ISS	4
GO:0097113	AMPA glutamate receptor clustering	biological process	ISS	2
GO:0007158	neuron cell-cell adhesion	biological process	ISS; TAS[15797875]	2
GO:0045211	postsynaptic membrane	cellular component	IEA	21
GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological process	ISS	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04514	Cell adhesion molecules (CAMs)	7

Gene related interactors from protein-protein interactions data in PINA v2 (count: 3)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
NLGN1	NRXN1	No	--	--	8576240 , 14522992 , 8576240
NLGN1	DLG3	No	--	--	9278515
NLGN1	NRXN3	Yes	--	--	8576240