PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Stein, M. B.,2016 PMID: 27167565
Citation	Stein, M. B., et al. (2016). "Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers." JAMA Psychiatry 73(7): 695-704.
Phenotype	PTSD diagnosis
Trauma	Combat
Study Design	Case-control
Study Type	Genome-wide association study
Sample Size	3167 cases, 4607 controls
SNP/Marker Size	1,025,161 SNPs
Predominant Ethnicity	Caucasian, Black
Population	American
Gender	NSS participants: 6277 males, 1497 females. PPDS participants: 5583 males, 333 females.
Age	NSS participants: mean age=20.9 years, SD=3.3. PPDS participants: mean age=26.5 years, SD=6.0.

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	A computerized version of the Composite International Diagnostic Interview Screening Scales, a screening version of the PTSD Checklist (PCL)
Sample Status	We tested the genetic correlation and pleiotropy of PTSD in all European American samples with psychiatric disorders (including schizophrenia, bipolar disorder, attention-deficit/hyperactivity disorder, major depressive disorder, autism spectrum disorder, and a cross-disorder phenotype)and with immune-related disorders (including Crohn disease, ulcerative colitis, multiple sclerosis, psoriasis, rheumatoid arthritis, systemic lupus erythematosis, celiac disease, primary biliary cirrhosis, and type 1 diabetes mellitus).
Controls Exposed	Yes
Replication Size	947 cases, 4969 controls
Result Summary	A genome-wide significant locuswas found in ANKRD55 on chromosome 5 and persisted after adjustment for cumulative trauma exposure in the African American samples from the NSS. A genome-wide significant locuswas also found in or near ZNF626 on chromosome 19 in the European American samples from the NSS. Similar results were not found for either single-nucleotide polymorphism in the corresponding ancestry group from the PPDS sample, in other ancestral groups, or in transancestral meta-analyses.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 2)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs11085374	PTSD diagnosis	ZNF626	Standard GWAS: EA: In NSS1 sample: OR=0.77, P-value=3.67E-06. In NSS2 sample: OR=0.77, P-value=3.62E-03. NSS sample meta-analysis: OR=0.77, P-value=4.59E-08. In PPDS sample: OR=1.05, P-value=0.5. All sample meta analysis: OR=0.86, P-value=5.4E-05. AA: In NSS1 sample: OR=0.95, P-value=0.63. In NSS2 sample: OR=1.1, P-value=0.62. NSS sample meta-analysis: OR=0.98, P-value=0.85. In PPDS sample: OR=0.96, P-value=0.79. All sample meta analysis: OR=0.98, P-value=0.77. LA: In NSS1 sample: OR=1.23, P-value=0.08. In NSS2 sample: OR=1.09, P-value=0.65. NSS sample meta-analysis: OR=1.19, P-value=0.08. In PPDS sample: OR=0.87, P-value=0.34. All sample meta analysis: OR=1.08, P-value=0.38. Trauma-Adjusted GWAS: EA: In NSS1 sample: OR=0.77, P-value=4.43E-06. In NSS2 sample: OR=0.76, P-value=2.54E-03. NSS sample meta-analysis: OR=0.77, P-value=4.05E-08. In PPDS sample: OR=1.04, P-value=0.56. All sample meta analysis: OR=0.85, P-value=2.92E-05. Sex, Age, and Lifetime Cumulative Trauma Adjusted GWAS: EA: In NSS1 sample: OR=0.77, P-value=3.9E-06. In NSS2 sample: OR=0.79, P-value=0.01. NSS sample meta-analysis: OR=0.78, P-value=1.75E-07. In PPDS sample: OR=1.03, P-value=0.65. All sample meta analysis: OR=0.85, P-value=5.98E-05.	A genome-wide significant locuswas also found in or near ZNF...... A genome-wide significant locuswas also found in or near ZNF626 on chromosome 19 (rs11085374) in the European American samples from the NSS. Similar results were not found in the corresponding ancestry group from the PPDS sample, in other ancestral groups, or in transancestral meta-analyses. More...	Significant
rs159572	PTSD diagnosis	ANKRD55	Standard GWAS: EA: In NSS1 sample: OR=1.00, P-value=0.93. In NSS2 sample: OR=0.84, P-value=0.045. NSS sample meta-analysis: OR=0.94, P-value=0.23. In PPDS sample: OR=0.94, P-value=0.36. All sample meta analysis: OR=0.94, P-value=0.13. AA: In NSS1 sample: OR=1.57, P-value=4.91E-06. In NSS2 sample: OR=1.74, P-value=1.16E-03. NSS sample meta-analysis: OR=1.62, P-value=2.34E-08. In PPDS sample: OR=1.18, P-value=0.28. All sample meta analysis: OR=1.51, P-value=6.18E-08. LA: In NSS1 sample: OR=1.07, P-value=0.52. In NSS2 sample: OR=0.82, P-value=0.21. NSS sample meta-analysis: OR=0.99, P-value=0.88. In PPDS sample: OR=0.81, P-value=0.07. All sample meta analysis: OR=0.92, P-value=0.23. Trauma-Adjusted GWAS: AA: In NSS1 sample: OR=1.61, P-value=2.57E-06. In NSS2 sample: OR=1.75, P-value=1.14E-03. NSS sample meta-analysis: OR=1.64, P-value=1.18E-08. In PPDS sample: OR=1.1, P-value=0.56. All sample meta analysis: OR=1.5, P-value=1.09E-07. Sex, Age, and Lifetime Cumulative Trauma Adjusted GWAS: AA: In NSS1 sample: OR=1.55, P-value=1.83E-05. In NSS2 sample: OR=1.75, P-value=2.52E-03. NSS sample meta-analysis: OR=1.60, P-value=1.86E-07. In PPDS sample: OR=1.07, P-value=0.68. All sample meta analysis: OR=1.46, P-value=1.75E-07.	A genome-wide significant locuswas found in ANKRD55 on chrom...... A genome-wide significant locuswas found in ANKRD55 on chromosome 5 (rs159572) and persisted after adjustment for cumulative trauma exposure in the African American samples from the NSS. Similar results were not found in the corresponding ancestry group from the PPDS sample, in other ancestral groups, or in transancestral meta-analyses. More...	Significant