PTSDgene database

SNP Report

Basic Info
Name rs77006546 dbSNP Ensembl
Location 6:25219354 - 25219354(+)
Variant Seq C
Ancestral Allele T
Ref Seq T
Minor Allele Frequence 0.0171725
Annotation downstream_gene_variant
Variant Effect downstream_gene_variant(ENST00000401481)
SIFT Annotation deleterious_-_low_confidence
SIFT Variant Effect deleterious_-_low_confidence(ENST00000510784)
PolyPhen Annotation probably_damaging
PolyPhen Variant Effect probably_damaging(ENST00000510784)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Enhancers;Weak transcription;Flanking Active TSS
No. of Marker's Association Results 1 (Positive: 0; Negative: 0; Trend: 1)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wolf, E. J.,2014 Dissociative symptom severity Linear regression: B=0.70, SE=0.38, P-value=9.60E-06, R Linear regression: B=0.70, SE=0.38, P-value=9.60E-06, R2=0.04. After covarying for PTSD severity (with PTSD severity in the model), P-value= .0002. More... It showed suggestive evidence of association with dissociati...... It showed suggestive evidence of association with dissociation. In follow-up analyses, the association between this SNP and dissociation severity remained significant after covarying for PTSD severity. More... Trend

SNP related genes (count: 0)

SNPs in LD with rs77006546 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx