Almli, L. M.,2015 |
PTSD Symptoms as measured by the quantitave CAPS scores |
In (SBPBC cohort) discovery stage: (sex and top three princ......
In (SBPBC cohort) discovery stage: (sex and top three principal components as covariates) N=147, B (SE)=31.34 (5.19), P-value=1.28E-08; categorical PTSD diagnosis measure: OR=8.6, 95%CI=3.5-21.6, P-value=3.84E-06; self-reported PTSD symptoms: N=147, B (SE)=17.37 (3.10), P-value=1.203E-07. The main effect of rs717947 for CAPS scores after controlling for early childhood trauma exposure or overall negative life events: [Covariate: Early Trauma Inventory, N=146, B (SE)=31.5 (5.2), P-value=1.13E-08; Negative life events, N=146, B (SE)=24.9 (4.3), P-value=3.29E-08]. In (GTP cohort) replication stage: in female, N=2006, OR=1.25, CI=1.1-1.5, P-value=0.005; in male, N=862, P-value=0.37
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The GWAS yielded one genome-wide significant SNP, rs717947 w......
The GWAS yielded one genome-wide significant SNP, rs717947 with current CAPS score. Sensitivity analysis covarying for self-reported race instead of the top three principal components showed similar results for the association between rs717947 and PTSD symptoms (data not shown). Follow-up analysis of SNP rs717947 showed that this SNP is robust to different measures of PTSD, both categorical and self-reported measures. In both cases, the main effect of rs717947 remained genome-wide significant for CAPS scores after controlling for early childhood trauma exposure or overall negative life events. In (GTP cohort) replication stage: in females, we found that carriers of the risk allele (T) had increased odds of PTSD diagnosis; in contrast, no association was found in males.
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Significant |