PTSDgene database

SNP Report

Basic Info
Name rs2466273 dbSNP Ensembl
Location 8:13008495 - 13008495(+)
Variant Seq C
Ancestral Allele C
Ref Seq A
Minor Allele Frequence 0.130391
Annotation downstream_gene_variant; upstream_gene_variant; intron_variant
Variant Effect downstream_gene_variant(ENST00000400069, ENST00000528335, ENST00000528753); upstream_gene_variant(ENST00000529978, ENST00000529706); intron_variant(ENST00000524591, ENST00000532376, ENST00000447063)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000524591)
PolyPhen Annotation probably_damaging
PolyPhen Variant Effect probably_damaging(ENST00000524591)
rSNP? Yes Link in rVarBase
Related Regulatory Elements TF binding region
Chromatin State Weak transcription;Strong transcription
No. of Marker's Association Results 1 (Positive: 0; Negative: 0; Trend: 1)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wolf, E. J.,2014 Dissociative symptom severity Linear regression: B=1.31, SE=0.29, P-value=7.10E-06, R Linear regression: B=1.31, SE=0.29, P-value=7.10E-06, R2=0.04. Sex and SNP effects were found for rs2466273: B(interaction) =-1.63, P-value= .007; B(men)=0.74, P-value=.04; B(women)=2.36, P-value=3E-06. More... It showed suggestive evidence of association with dissociati...... It showed suggestive evidence of association with dissociation. In follow-up analyses, the association between this SNP and dissociation severity remained significant after covarying for PTSD severity. And it showed suggestive evidence of an association with sex, such that the effects were greater in women compared to men. More... Trend

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
KIAA1456 KIAA1456 8p22 1(0/0/1)

SNPs in LD with rs2466273 (count: 10)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 9)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-259G18.3 No Adipose Subcutaneous cis GTEx