SNP Report

Basic Info

Name	rs2466273 dbSNP Ensembl
Location	8:13008495 - 13008495(+)
Variant Seq	C
Ancestral Allele	C
Ref Seq	A
Minor Allele Frequence	0.130391
Annotation	downstream_gene_variant; upstream_gene_variant; intron_variant
Variant Effect	downstream_gene_variant(ENST00000400069, ENST00000528335, ENST00000528753); upstream_gene_variant(ENST00000529978, ENST00000529706); intron_variant(ENST00000524591, ENST00000532376, ENST00000447063)
SIFT Annotation	tolerated
SIFT Variant Effect	tolerated(ENST00000524591)
PolyPhen Annotation	probably_damaging
PolyPhen Variant Effect	probably_damaging(ENST00000524591)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	TF binding region
Chromatin State	Weak transcription;Strong transcription
No. of Marker's Association Results	1 (Positive: 0; Negative: 0; Trend: 1)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Wolf, E. J.,2014	Dissociative symptom severity	Linear regression: B=1.31, SE=0.29, P-value=7.10E-06, R Linear regression: B=1.31, SE=0.29, P-value=7.10E-06, R²=0.04. Sex and SNP effects were found for rs2466273: B(interaction) =-1.63, P-value= .007; B(men)=0.74, P-value=.04; B(women)=2.36, P-value=3E-06. More...	It showed suggestive evidence of association with dissociati...... It showed suggestive evidence of association with dissociation. In follow-up analyses, the association between this SNP and dissociation severity remained significant after covarying for PTSD severity. And it showed suggestive evidence of an association with sex, such that the effects were greater in women compared to men. More...	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
KIAA1456	KIAA1456	8p22	1(0/0/1)

SNPs in LD with rs2466273 (count: 10)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Annotation	No. of Association Results(Positive/Negative/Trend)	r²[population]

rs2460905	intron_variant(ENST00000524591, ENST00000532376, ENST00000525249, ENST00000528753, ENST00000528335, ENST00000400069, ENST00000447063); non_coding_transcript_variant(ENST00000525249, ENST00000528335)	1(0/0/1)	0.8865[EUR]

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs6992991	rs2460905 rs2466273	downstream_gene_variant; upstream_gene_variant; intron_variant	0.9837[EUR]
rs2460898	rs2460905 rs2466273	intron_variant; non_coding_transcript_variant	0.8865[EUR]
rs2466255	rs2460905 rs2466273	intron_variant; non_coding_transcript_variant	0.8865[EUR]
rs2466256	rs2460905 rs2466273	intron_variant; non_coding_transcript_variant	0.8865[EUR]
rs2460903	rs2460905 rs2466273	intron_variant; non_coding_transcript_variant	0.8865[EUR]
rs73204351	rs2460905 rs2466273	intron_variant; non_coding_transcript_variant	0.8865[EUR]
rs2460906	rs2460905 rs2466273	intron_variant; non_coding_transcript_variant	0.8539[EUR]
rs2460346	rs2460905 rs2466273	intron_variant; non_coding_transcript_variant	0.9183[EUR]
rs2460347	rs2460905 rs2466273	intron_variant; non_coding_transcript_variant	0.8865[EUR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
RP11-259G18.3	No	Adipose Subcutaneous	cis	GTEx