PTSDgene database

SNP Report

Basic Info
Name rs1915919 dbSNP Ensembl
Location 3:20042389 - 20042389(+)
Variant Seq T
Ancestral Allele T
Ref Seq C
Minor Allele Frequence 0.276757
Annotation intron_variant; non_coding_transcript_variant
Variant Effect intron_variant(ENST00000263754, ENST00000426228); non_coding_transcript_variant(ENST00000426228)
SIFT Annotation deleterious
SIFT Variant Effect deleterious(ENST00000263754)
PolyPhen Annotation probably_damaging
PolyPhen Variant Effect probably_damaging(ENST00000263754)
rSNP? Yes Link in rVarBase
Related Regulatory Elements Chromatin interactive region
Chromatin State Weak transcription;Enhancers;Genic enhancers;Flanking Active TSS;Active TSS
No. of Marker's Association Results 1 (Positive: 0; Negative: 0; Trend: 1)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wolf, E. J.,2014 Dissociative symptom severity Linear regression: B=0.74, SE=0.16, P-value=7.99E-06, R Linear regression: B=0.74, SE=0.16, P-value=7.99E-06, R2=0.04. More... It showed suggestive evidence of association with dissociati...... It showed suggestive evidence of association with dissociation. In follow-up analyses, the association between this SNP and dissociation severity remained significant after covarying for PTSD severity. More... Trend

SNP related genes (count: 3)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
EFHB EF-hand domain family member B 3p24.3 rSNP target
KAT2B K(lysine) acetyltransferase 2B 3p24 1(0/0/1)
RAB5A RAB5A, member RAS oncogene family 3p24.3 rSNP target

SNPs in LD with rs1915919 (count: 1)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
LRRC37A4P No Adipose Subcutaneous cis GTEx