Gene Report

Basic Info

Approved Symbol	PSMA4
Symbol Alias	"HC9\|HsT17706"
Approved Name	proteasome subunit alpha 4
Previous Name	proteasome (prosome, macropain) subunit, alpha type, 4
Location	15q24.1
Position	chr15:78540405-78552419, 1
External Links	HGNC: 9533 Entrez Gene: 5685 Ensembl: ENSG00000041357 UCSC: uc010blf.3
No. of Association Results	0. Gene is from "Mapped by LD-proxy, rSNP target"
Annotation Type	Mapped by LD-proxy, rSNP target

Gene functional annotation

Gene related GO terms (count: 52)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	2
GO:0006915	apoptotic process	biological process	TAS	19
GO:0033209	tumor necrosis factor-mediated signaling pathway	biological process	TAS	6
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	TAS	2
GO:0005634	nucleus	cellular component	IDA[21630459]	81
GO:0007411	axon guidance	biological process	TAS	16
GO:0005829	cytosol	cellular component	TAS	78
GO:0005737	cytoplasm	cellular component	IDA	109
GO:0043066	negative regulation of apoptotic process	biological process	TAS	9
GO:0012501	programmed cell death	biological process	TAS	4
GO:0000209	protein polyubiquitination	biological process	TAS	4
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	biological process	TAS	4
GO:0006521	regulation of cellular amino acid metabolic process	biological process	TAS	1
GO:0045087	innate immune response	biological process	TAS	15
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	biological process	TAS	3
GO:0005839	proteasome core complex	cellular component	ISS	1
GO:0007265	Ras protein signal transduction	biological process	TAS	8
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	biological process	TAS	3
GO:0090263	positive regulation of canonical Wnt signaling pathway	biological process	TAS	2
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS	9
GO:0038061	NIK/NF-kappaB signaling	biological process	TAS	1
GO:0000502	proteasome complex	cellular component	IDA[17323924]	2
GO:0019773	proteasome core complex, alpha-subunit complex	cellular component	IEA	1
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	9
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS	2
GO:0010467	gene expression	biological process	TAS	16
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	11
GO:0070062	extracellular exosome	cellular component	IDA[19056867\|20458337\|23376485]	58
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	1
GO:0043488	regulation of mRNA stability	biological process	TAS	2
GO:0090090	negative regulation of canonical Wnt signaling pathway	biological process	TAS	2
GO:0005654	nucleoplasm	cellular component	TAS	43
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS	4
GO:0042981	regulation of apoptotic process	biological process	TAS	3
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	11
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition	biological process	TAS	2
GO:0005515	protein binding	molecular function	IPI[12376572\|14733938\|15225636\|15887188\|17948026\|25416956]	169
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	14
GO:0006595	polyamine metabolic process	biological process	TAS	2
GO:0002223	stimulatory C-type lectin receptor signaling pathway	biological process	TAS	3
GO:0000278	mitotic cell cycle	biological process	TAS	7
GO:0008286	insulin receptor signaling pathway	biological process	TAS	8
GO:0000186	activation of MAPKK activity	biological process	TAS	7
GO:0004298	threonine-type endopeptidase activity	molecular function	IEA	1
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	9
GO:0016032	viral process	biological process	TAS	8
GO:0050852	T cell receptor signaling pathway	biological process	TAS	3
GO:0000165	MAPK cascade	biological process	TAS	10
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	11
GO:0000932	cytoplasmic mRNA processing body	cellular component	ISS	3
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	8

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa03050	Proteasome	1

Gene related interactors from protein-protein interactions data in PINA v2 (count: 65)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
PSMA4	USP9X	No	biochemical	colocalization	22939629
PSMA4	PSMA5	No	biochemical	association, colocalization	12376572 , 15225636 , 17948026 , 7811265 , 15887188 , 12376572 , 15225636 , 15225636 , 15225636 , 15225636 , 15225636 , 15225636 , 22939629 , 9311996 , 15225636 , 15225636 , 22863883
PSMA4	PSMB3	No	biochemical	association, colocalization	12376572 , 17948026 , 7811265 , 15887188 , 12376572 , 22863883 , 22939629
PSMA4	KIF5B	No	biochemical	colocalization	22863883
PSMA4	RNF185	No	--	--	17558393
PSMA4	PSMD2	No	biochemical	colocalization	22939629
PSMA4	PSME3	No	biochemical	colocalization	22939629
PSMA4	NFKBIA	No	--	--	9875328 , 9875328
PSMA4	PSMB5	No	biochemical	association, colocalization	12376572 , 7811265 , 12376572 , 22863883 , 9311996 , 22939629
PSMA4	SMURF1	No	--	--	23184937
PSMA4	SIRT3	No	--	--	22318606
PSMA4	PSMD7	No	biochemical	colocalization	22939629 , 19581590
PSMA4	SLX1A	No	--	association	19596235 , 19596235
PSMA4	NEDD8	No	--	--	16503656
PSMA4	PLK1	No	--	--	11205743 , 11205743 , 11205743 , 11205743
PSMA4	E2F4	No	--	colocalization	15782160
PSMA4	TRAF6	No	--	--	14743216 , 14743216 , 14743216
PSMA4	PSME2	No	--	--	11745344
PSMA4	IQCB1	No	--	association	21565611 , 21565611 , 21565611
PSMA4	PSMC5	No	biochemical	colocalization	22939629
PSMA4	PSMD5	No	biochemical	colocalization	22939629
PSMA4	PSMC4	No	biochemical	colocalization	22939629
PSMA4	PSMA6	No	biochemical	association, colocalization	12376572 , 17948026 , 17948026 , 17948026 , 17948026 , 15225636 , 19581590 , 17948026 , 19581590 , 7811265 , 15887188 , 17948026 , 15225636 , 16759355 , 15225636 , 15225636 , 22863883 , 15225636 , 15225636 , 15225636 , 15225636 , 9311996 , 22939629 , 15225636 , 19581590 , 17948026 , 17948026 , 17948026 , 17948026 , 17948026
PSMA4	PSMB4	No	biochemical	association, colocalization	12376572 , 17948026 , 7811265 , 15887188 , 12376572 , 9311996 , 22863883 , 22939629
PSMA4	SIRT2	No	--	--	22318606
PSMA4	PSMD1	No	biochemical	colocalization	22939629
PSMA4	PSMA8	No	biochemical	colocalization	22939629
PSMA4	POMP	No	biochemical	colocalization	17948026 , 17948026 , 17948026 , 17948026 , 17948026 , 17948026
PSMA4	PSMB6	No	biochemical	association, colocalization	12376572 , 17948026 , 7811265 , 15887188 , 12376572 , 22939629 , 22863883 , 9311996
PSMA4	PSMD13	No	biochemical	colocalization	22939629
PSMA4	FBXO6	No	--	--	22268729
PSMA4	BHLHE41	No	--	--	22801492
PSMA4	HDAC2	No	--	--	22318606
PSMA4	PSMB9	No	--	--	7811265 , 15887188 , 9311996
PSMA4	BABAM1	No	--	--	19615732 , 19615732
PSMA4	SIRT1	No	--	--	22318606 , 22318606
PSMA4	PSMB2	No	biochemical	association, colocalization	12376572 , 17948026 , 7811265 , 15887188 , 12376572 , 22863883 , 22939629
PSMA4	NOS2	No	--	--	23438482
PSMA4	PSMB8	No	biochemical	colocalization	7811265 , 15887188 , 22863883 , 15303969 , 9311996 , 22939629
PSMA4	RPS27A	No	--	--	19581590 , 19581590 , 19581590
PSMA4	RPP38	No	biochemical	colocalization	22863883
PSMA4	VCP	No	biochemical	colocalization	22939629
PSMA4	PYCRL	No	biochemical	colocalization	22863883
PSMA4	PSMC6	No	biochemical	colocalization	22939629
PSMA4	PSMB7	No	biochemical	association, colocalization	12376572 , 20723761 , 20723761 , 7811265 , 15887188 , 20723761 , 22939629 , 16423992 , 20723761 , 22863883 , 9311996 , 20723761 , 12376572 , 20723761 , 20723761
PSMA4	PSMD6	No	biochemical	colocalization	22939629
PSMA4	PSME1	No	--	--	11745344
PSMA4	ASB10	No	--	--	23901248
PSMA4	EPB41L1	No	biochemical	colocalization	22863883
PSMA4	PSMD8	No	biochemical	colocalization	22939629
PSMA4	AP3M1	No	biochemical	colocalization	22863883
PSMA4	NRF1	No	--	colocalization	24250222
PSMA4	PSMD4	No	biochemical	colocalization	22939629
PSMA4	PSME4	No	biochemical	colocalization	22863883
PSMA4	PSMC1	No	biochemical	colocalization	22939629
PSMA4	FKBP8	No	--	--	17573772
PSMA4	RAD23A	No	--	--	19013454
PSMA4	STK24	No	--	--	23455922
PSMA4	PSMC2	No	biochemical	colocalization	19581590 , 22939629
PSMA4	UCHL5	Yes	--	association	18922472 , 19490896 , 18922472 , 18922472
PSMA4	CSNK2A1	No	--	--	8619999 , 8619999
PSMA4	PSMG2	No	biochemical	association	17948026 , 17948026 , 17948026 , 17948026
PSMA4	YBX1	No	biochemical	colocalization	22939629
PSMA4	CUL1	No	--	--	21145461 , 16759355
PSMA4	SUMO2	No	--	--	19471022