Gene Report

Basic Info

Approved Symbol	PSMA4
Symbol Alias	"HC9\|HsT17706"
Approved Name	proteasome subunit alpha 4
Previous Name	proteasome (prosome, macropain) subunit, alpha type, 4
Location	15q24.1
Position	chr15:78540405-78552419, 1
External Links	HGNC: 9533 Entrez Gene: 5685 Ensembl: ENSG00000041357 UCSC: uc010blf.3
No. of Association Results	0. Gene is from "Mapped by LD-proxy, rSNP target"
Annotation Type	Mapped by LD-proxy, rSNP target

Gene functional annotation

Gene related GO terms (count: 52)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	2
GO:0006915	apoptotic process	biological process	TAS	19
GO:0033209	tumor necrosis factor-mediated signaling pathway	biological process	TAS	6
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	TAS	2
GO:0005634	nucleus	cellular component	IDA[21630459]	81
GO:0007411	axon guidance	biological process	TAS	16
GO:0005829	cytosol	cellular component	TAS	78
GO:0005737	cytoplasm	cellular component	IDA	109
GO:0043066	negative regulation of apoptotic process	biological process	TAS	9
GO:0012501	programmed cell death	biological process	TAS	4
GO:0000209	protein polyubiquitination	biological process	TAS	4
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	biological process	TAS	4
GO:0006521	regulation of cellular amino acid metabolic process	biological process	TAS	1
GO:0045087	innate immune response	biological process	TAS	15
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	biological process	TAS	3
GO:0005839	proteasome core complex	cellular component	ISS	1
GO:0007265	Ras protein signal transduction	biological process	TAS	8
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	biological process	TAS	3
GO:0090263	positive regulation of canonical Wnt signaling pathway	biological process	TAS	2
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS	9
GO:0038061	NIK/NF-kappaB signaling	biological process	TAS	1
GO:0000502	proteasome complex	cellular component	IDA[17323924]	2
GO:0019773	proteasome core complex, alpha-subunit complex	cellular component	IEA	1
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	9
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS	2
GO:0010467	gene expression	biological process	TAS	16
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	11
GO:0070062	extracellular exosome	cellular component	IDA[19056867\|20458337\|23376485]	58
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	1
GO:0043488	regulation of mRNA stability	biological process	TAS	2
GO:0090090	negative regulation of canonical Wnt signaling pathway	biological process	TAS	2
GO:0005654	nucleoplasm	cellular component	TAS	43
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS	4
GO:0042981	regulation of apoptotic process	biological process	TAS	3
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	11
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition	biological process	TAS	2
GO:0005515	protein binding	molecular function	IPI[12376572\|14733938\|15225636\|15887188\|17948026\|25416956]	169
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	14
GO:0006595	polyamine metabolic process	biological process	TAS	2
GO:0002223	stimulatory C-type lectin receptor signaling pathway	biological process	TAS	3
GO:0000278	mitotic cell cycle	biological process	TAS	7
GO:0008286	insulin receptor signaling pathway	biological process	TAS	8
GO:0000186	activation of MAPKK activity	biological process	TAS	7
GO:0004298	threonine-type endopeptidase activity	molecular function	IEA	1
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA	9
GO:0016032	viral process	biological process	TAS	8
GO:0050852	T cell receptor signaling pathway	biological process	TAS	3
GO:0000165	MAPK cascade	biological process	TAS	10
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	11
GO:0000932	cytoplasmic mRNA processing body	cellular component	ISS	3
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	8

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa03050	Proteasome	1

Gene related interactors from protein-protein interactions data in PINA v2 (count: 65)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
PSMA4	PSMC5	No	biochemical	colocalization	22939629
PSMA4	RAD23A	No	--	--	19013454
PSMA4	PYCRL	No	biochemical	colocalization	22863883
PSMA4	NEDD8	No	--	--	16503656
PSMA4	PSMD1	No	biochemical	colocalization	22939629
PSMA4	PSMA8	No	biochemical	colocalization	22939629
PSMA4	IQCB1	No	--	association	21565611 , 21565611 , 21565611
PSMA4	NOS2	No	--	--	23438482
PSMA4	PSMG2	No	biochemical	association	17948026 , 17948026 , 17948026 , 17948026
PSMA4	HDAC2	No	--	--	22318606
PSMA4	PSMB4	No	biochemical	association, colocalization	12376572 , 17948026 , 7811265 , 15887188 , 12376572 , 9311996 , 22863883 , 22939629
PSMA4	PSME1	No	--	--	11745344
PSMA4	PSMD13	No	biochemical	colocalization	22939629
PSMA4	PSMD7	No	biochemical	colocalization	22939629 , 19581590
PSMA4	PSMB9	No	--	--	7811265 , 15887188 , 9311996
PSMA4	PSMC4	No	biochemical	colocalization	22939629
PSMA4	TRAF6	No	--	--	14743216 , 14743216 , 14743216
PSMA4	PSMD4	No	biochemical	colocalization	22939629
PSMA4	PSMC1	No	biochemical	colocalization	22939629
PSMA4	PSMA6	No	biochemical	association, colocalization	12376572 , 17948026 , 17948026 , 17948026 , 17948026 , 15225636 , 19581590 , 17948026 , 19581590 , 7811265 , 15887188 , 17948026 , 15225636 , 16759355 , 15225636 , 15225636 , 22863883 , 15225636 , 15225636 , 15225636 , 15225636 , 9311996 , 22939629 , 15225636 , 19581590 , 17948026 , 17948026 , 17948026 , 17948026 , 17948026
PSMA4	PSMD6	No	biochemical	colocalization	22939629
PSMA4	PSMB7	No	biochemical	association, colocalization	12376572 , 20723761 , 20723761 , 7811265 , 15887188 , 20723761 , 22939629 , 16423992 , 20723761 , 22863883 , 9311996 , 20723761 , 12376572 , 20723761 , 20723761
PSMA4	BABAM1	No	--	--	19615732 , 19615732
PSMA4	KIF5B	No	biochemical	colocalization	22863883
PSMA4	PSMC2	No	biochemical	colocalization	19581590 , 22939629
PSMA4	PSMD5	No	biochemical	colocalization	22939629
PSMA4	VCP	No	biochemical	colocalization	22939629
PSMA4	PSMB8	No	biochemical	colocalization	7811265 , 15887188 , 22863883 , 15303969 , 9311996 , 22939629
PSMA4	SIRT1	No	--	--	22318606 , 22318606
PSMA4	USP9X	No	biochemical	colocalization	22939629
PSMA4	PSMC6	No	biochemical	colocalization	22939629
PSMA4	EPB41L1	No	biochemical	colocalization	22863883
PSMA4	PSMB6	No	biochemical	association, colocalization	12376572 , 17948026 , 7811265 , 15887188 , 12376572 , 22939629 , 22863883 , 9311996
PSMA4	PSMB2	No	biochemical	association, colocalization	12376572 , 17948026 , 7811265 , 15887188 , 12376572 , 22863883 , 22939629
PSMA4	PSME3	No	biochemical	colocalization	22939629
PSMA4	POMP	No	biochemical	colocalization	17948026 , 17948026 , 17948026 , 17948026 , 17948026 , 17948026
PSMA4	BHLHE41	No	--	--	22801492
PSMA4	FBXO6	No	--	--	22268729
PSMA4	AP3M1	No	biochemical	colocalization	22863883
PSMA4	PSME4	No	biochemical	colocalization	22863883
PSMA4	SMURF1	No	--	--	23184937
PSMA4	SIRT3	No	--	--	22318606
PSMA4	PSMB5	No	biochemical	association, colocalization	12376572 , 7811265 , 12376572 , 22863883 , 9311996 , 22939629
PSMA4	PSMB3	No	biochemical	association, colocalization	12376572 , 17948026 , 7811265 , 15887188 , 12376572 , 22863883 , 22939629
PSMA4	SLX1A	No	--	association	19596235 , 19596235
PSMA4	RNF185	No	--	--	17558393
PSMA4	UCHL5	Yes	--	association	18922472 , 19490896 , 18922472 , 18922472
PSMA4	YBX1	No	biochemical	colocalization	22939629
PSMA4	FKBP8	No	--	--	17573772
PSMA4	E2F4	No	--	colocalization	15782160
PSMA4	PSME2	No	--	--	11745344
PSMA4	RPP38	No	biochemical	colocalization	22863883
PSMA4	CSNK2A1	No	--	--	8619999 , 8619999
PSMA4	CUL1	No	--	--	21145461 , 16759355
PSMA4	PSMA5	No	biochemical	association, colocalization	12376572 , 15225636 , 17948026 , 7811265 , 15887188 , 12376572 , 15225636 , 15225636 , 15225636 , 15225636 , 15225636 , 15225636 , 22939629 , 9311996 , 15225636 , 15225636 , 22863883
PSMA4	PSMD2	No	biochemical	colocalization	22939629
PSMA4	ASB10	No	--	--	23901248
PSMA4	SIRT2	No	--	--	22318606
PSMA4	STK24	No	--	--	23455922
PSMA4	RPS27A	No	--	--	19581590 , 19581590 , 19581590
PSMA4	SUMO2	No	--	--	19471022
PSMA4	NRF1	No	--	colocalization	24250222
PSMA4	PLK1	No	--	--	11205743 , 11205743 , 11205743 , 11205743
PSMA4	NFKBIA	No	--	--	9875328 , 9875328
PSMA4	PSMD8	No	biochemical	colocalization	22939629