Gene Report

Basic Info

Approved Symbol	IL1A
Previous Symbol	IL1
Symbol Alias	"IL1F1\|IL-1A\|IL1-ALPHA"
Approved Name	interleukin 1 alpha
Name Alias	"preinterleukin 1 alpha\|hematopoietin-1\|pro-interleukin-1-alpha"
Location	2q14
Position	chr2:112773915-112784590, -1
External Links	HGNC: 5991 Entrez Gene: 3552 Ensembl: ENSG00000115008 UCSC: uc002tig.3
No. of Association Results	0. Gene is from "rSNP target"
Annotation Type	rSNP target

Gene functional annotation

Gene related GO terms (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0010628	positive regulation of gene expression	biological process	IDA[23817958]	14
GO:0035234	ectopic germ cell programmed cell death	biological process	IEA	2
GO:0002437	inflammatory response to antigenic stimulus	biological process	IBA	3
GO:0001660	fever generation	biological process	IBA	2
GO:0034605	cellular response to heat	biological process	IDA[12746488]	1
GO:0045086	positive regulation of interleukin-2 biosynthetic process	biological process	IMP[2989698]	2
GO:0008283	cell proliferation	biological process	TAS[6209582]	9
GO:0005149	interleukin-1 receptor binding	molecular function	IBA	2
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IBA	10
GO:0005125	cytokine activity	molecular function	IMP[2989698]	7
GO:0019221	cytokine-mediated signaling pathway	biological process	IMP[2989698]	9
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	25
GO:0045766	positive regulation of angiogenesis	biological process	ISS	5
GO:0050714	positive regulation of protein secretion	biological process	IMP[9564845]	2
GO:0008285	negative regulation of cell proliferation	biological process	IDA[3493774]	13
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	biological process	TAS[10748004]	3
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IBA	5
GO:0005829	cytosol	cellular component	IDA[12746488]	78
GO:0046688	response to copper ion	biological process	IDA[12746488]	2
GO:0005515	protein binding	molecular function	IPI[12746488\|18329368]	169
GO:0046330	positive regulation of JNK cascade	biological process	IBA	3
GO:0005507	copper ion binding	molecular function	IDA[12746488]	3
GO:0010575	positive regulation of vascular endothelial growth factor production	biological process	ISS	3
GO:0002248	connective tissue replacement involved in inflammatory response wound healing	biological process	IEA	1
GO:0005615	extracellular space	cellular component	IDA[12746488]; IMP[3493774]	27
GO:0006915	apoptotic process	biological process	TAS[1924307]	19
GO:0005576	extracellular region	cellular component	TAS	31
GO:0045840	positive regulation of mitotic nuclear division	biological process	IMP[2989698]	3
GO:0050715	positive regulation of cytokine secretion	biological process	IDA[1739124]	2
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	biological process	IEA	2
GO:0006954	inflammatory response	biological process	TAS[6209582]	10

Gene related KEGG pathways (count: 6)

ID	Name	No. of Genes in PTSDgene
hsa04210	Apoptosis	6
hsa04940	Type I diabetes mellitus	8
hsa04640	Hematopoietic cell lineage	5
hsa04010	MAPK signaling pathway	13
hsa04060	Cytokine-cytokine receptor interaction	9
hsa05332	Graft-versus-host disease	7

Gene related interactors from protein-protein interactions data in PINA v2 (count: 8)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
IL1A	S100A13	No	--	--	12746488 , 12746488
IL1A	CAPN1	No	--	--	7499244
IL1A	NDN	No	--	--	12913118 , 12913118 , 12913118
IL1A	IL1R1	No	--	--	2946959
IL1A	CASP1	No	--	--	18329368 , 18329368 , 18329368 , 18329368
IL1A	SHARPIN	No	--	--	21947080
IL1A	IL1RAP	No	--	--	9820540
IL1A	IL1R2	No	--	--	7878046