Gene Report

Basic Info

Approved Symbol	HLA-G
Approved Name	major histocompatibility complex, class I, G
Previous Name	HLA-G histocompatibility antigen, class I, G
Name Alias	b2 microglobulin
Location	6p21.3
Position	chr6:29826967-29831125, 1
External Links	HGNC: 4964 Entrez Gene: 3135 Ensembl: ENSG00000204632 UCSC: uc003nnw.2
No. of Association Results	0. Gene is from "Mapped by LD-proxy"
Annotation Type	Mapped by LD-proxy

Gene functional annotation

Gene related GO terms (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0005102	receptor binding	molecular function	IPI[20702625\|22802125]	13
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	biological process	TAS	3
GO:0050776	regulation of immune response	biological process	TAS	3
GO:0042130	negative regulation of T cell proliferation	biological process	IDA[20702625]	3
GO:0042605	peptide antigen binding	molecular function	IEA	2
GO:0012507	ER to Golgi transport vesicle membrane	cellular component	TAS	2
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	biological process	TAS	2
GO:0060333	interferon-gamma-mediated signaling pathway	biological process	TAS	5
GO:0030670	phagocytic vesicle membrane	cellular component	TAS	2
GO:0050777	negative regulation of immune response	biological process	IC[22802125]	2
GO:0019882	antigen processing and presentation	biological process	IBA	3
GO:0003823	antigen binding	molecular function	IBA	2
GO:0000139	Golgi membrane	cellular component	TAS	12
GO:0005886	plasma membrane	cellular component	IBA; TAS	99
GO:0042803	protein homodimerization activity	molecular function	IDA[22802125]; NAS[18550825]	18
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS	9
GO:0006968	cellular defense response	biological process	TAS[9539768]	2
GO:0002645	positive regulation of tolerance induction	biological process	IMP[22802125]	1
GO:0031901	early endosome membrane	cellular component	TAS	2
GO:0045591	positive regulation of regulatory T cell differentiation	biological process	IMP[20448110]	1
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane	cellular component	TAS	3
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	biological process	TAS	3
GO:0042612	MHC class I protein complex	cellular component	IEA	2
GO:0032735	positive regulation of interleukin-12 production	biological process	IDA[20702625]	2
GO:0002666	positive regulation of T cell tolerance induction	biological process	IMP[20448110]	1
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS	4
GO:2001199	negative regulation of dendritic cell differentiation	biological process	IDA[20702625]	1
GO:0016020	membrane	cellular component	IDA[19946888]	42
GO:0060337	type I interferon signaling pathway	biological process	TAS	3
GO:0002767	immune response-inhibiting cell surface receptor signaling pathway	biological process	IDA[20702625]	1

Gene related KEGG pathways (count: 7)

ID	Name	No. of Genes in PTSDgene
hsa04940	Type I diabetes mellitus	8
hsa04650	Natural killer cell mediated cytotoxicity	7
hsa04514	Cell adhesion molecules (CAMs)	7
hsa05330	Allograft rejection	5
hsa05332	Graft-versus-host disease	7
hsa05320	Autoimmune thyroid disease	3
hsa04612	Antigen processing and presentation	3

Gene related interactors from protein-protein interactions data in PINA v2 (count: 10)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
HLA-G	TAP2	No	--	--	9103419
HLA-G	TAP1	No	--	--	9103419
HLA-G	KIR2DL4	No	--	--	10190900
HLA-G	LILRB1	No	--	--	12853576
HLA-G	HLA-A	No	--	--	17353931
HLA-G	KLRD1	No	--	--	9405670
HLA-G	FAF2	No	biochemical	colocalization	22939629
HLA-G	LILRB2	No	--	--	12853576
HLA-G	B2M	No	--	--	9228302 , 9545232
HLA-G	COPB1	No	--	--	12582157