Gene Report

Basic Info

Approved Symbol	HLA-F
Approved Name	major histocompatibility complex, class I, F
Location	6p21.3
Position	chr6:29722775-29738528, 1
External Links	HGNC: 4963 Entrez Gene: 3134 Ensembl: ENSG00000204642 UCSC: uc003nno.4
No. of Association Results	0. Gene is from "rSNP target"
Annotation Type	rSNP target

Gene functional annotation

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane	cellular component	TAS	3
GO:0009986	cell surface	cellular component	IDA[20865824]	21
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	biological process	TAS	3
GO:0042612	MHC class I protein complex	cellular component	IEA	2
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS	9
GO:0030670	phagocytic vesicle membrane	cellular component	TAS	2
GO:0031901	early endosome membrane	cellular component	TAS	2
GO:0005783	endoplasmic reticulum	cellular component	IDA[10605026]	20
GO:0046978	TAP1 binding	molecular function	IPI[10605026]	1
GO:0016020	membrane	cellular component	IDA[19946888]	42
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	IBA; TAS	4
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	biological process	TAS	2
GO:0042605	peptide antigen binding	molecular function	IBA	2
GO:0000139	Golgi membrane	cellular component	TAS	12
GO:0005102	receptor binding	molecular function	IBA	13
GO:0060333	interferon-gamma-mediated signaling pathway	biological process	TAS	5
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	biological process	TAS	3
GO:0046979	TAP2 binding	molecular function	IPI[10605026]	1
GO:0005886	plasma membrane	cellular component	IBA; TAS	99
GO:0050776	regulation of immune response	biological process	TAS	3
GO:0012507	ER to Golgi transport vesicle membrane	cellular component	TAS	2
GO:0060337	type I interferon signaling pathway	biological process	TAS	3

Gene related KEGG pathways (count: 6)

ID	Name	No. of Genes in PTSDgene
hsa04940	Type I diabetes mellitus	8
hsa04514	Cell adhesion molecules (CAMs)	7
hsa05330	Allograft rejection	5
hsa05332	Graft-versus-host disease	7
hsa05320	Autoimmune thyroid disease	3
hsa04612	Antigen processing and presentation	3

Gene related interactors from protein-protein interactions data in PINA v2 (count: 4)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
HLA-F	LILRB2	No	--	--	11169396 , 11169396
HLA-F	TAP1	No	--	--	11169396
HLA-F	B2M	No	--	--	9545232 , 11169396
HLA-F	LILRB1	No	--	--	11169396 , 11169396