Gene Report

Basic Info

Approved Symbol	APOA5
Symbol Alias	"RAP3\|APOA-V"
Approved Name	apolipoprotein A-V
Location	11q23
Position	chr11:116789367-116792420, -1
External Links	HGNC: 17288 Entrez Gene: 116519 Ensembl: ENSG00000110243 UCSC: uc009yzf.3
No. of Association Results	0. Gene is from "rSNP target"
Annotation Type	rSNP target

Gene functional annotation

Gene related GO terms (count: 47)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0043691	reverse cholesterol transport	biological process	IBA	4
GO:0033700	phospholipid efflux	biological process	IBA	5
GO:0034380	high-density lipoprotein particle assembly	biological process	IBA	3
GO:0030300	regulation of intestinal cholesterol absorption	biological process	IBA	2
GO:0017127	cholesterol transporter activity	molecular function	IBA	4
GO:0060230	lipoprotein lipase activator activity	molecular function	IDA[18635818]	1
GO:0019899	enzyme binding	molecular function	IDA[15178420]	13
GO:0005543	phospholipid binding	molecular function	IDA[12810715]	7
GO:0042246	tissue regeneration	biological process	IEP[11577099]	1
GO:0008289	lipid binding	molecular function	IDA[12810715]	3
GO:0015485	cholesterol binding	molecular function	IBA	4
GO:0008201	heparin binding	molecular function	IDA[15878877\|17326667]	4
GO:0050996	positive regulation of lipid catabolic process	biological process	IDA[16806135]	2
GO:0046470	phosphatidylcholine metabolic process	biological process	IBA	1
GO:0060229	lipase activator activity	molecular function	IMP[15178420]	1
GO:0008047	enzyme activator activity	molecular function	IDA[16806135]	4
GO:0010898	positive regulation of triglyceride catabolic process	biological process	IDA[18635818]	2
GO:0048260	positive regulation of receptor-mediated endocytosis	biological process	TAS[18635818]	2
GO:0044255	cellular lipid metabolic process	biological process	TAS	3
GO:0055090	acylglycerol homeostasis	biological process	IDA[11588264]; IMP[15178420]	1
GO:0051006	positive regulation of lipoprotein lipase activity	biological process	IDA[15178420\|16806135\|18635818]	2
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0042627	chylomicron	cellular component	IDA[15528295]	6
GO:0034362	low-density lipoprotein particle	cellular component	IDA[15528295]	3
GO:0070325	lipoprotein particle receptor binding	molecular function	IPI[18635818]	1
GO:0010873	positive regulation of cholesterol esterification	biological process	IBA	4
GO:0006869	lipid transport	biological process	IDA[15178420]	3
GO:0031210	phosphatidylcholine binding	molecular function	IDA[16806135]	3
GO:0072562	blood microparticle	cellular component	IBA	5
GO:0005615	extracellular space	cellular component	IDA[18635818\|19121291]	27
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	IBA	4
GO:0042157	lipoprotein metabolic process	biological process	IBA	6
GO:0034364	high-density lipoprotein particle	cellular component	IDA[15528295]	5
GO:0042632	cholesterol homeostasis	biological process	IDA[19121291]	8
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling	biological process	IDA[18635818]	1
GO:0070328	triglyceride homeostasis	biological process	IDA[19121291]; IMP[18635818]	5
GO:0034372	very-low-density lipoprotein particle remodeling	biological process	IBA	3
GO:0019433	triglyceride catabolic process	biological process	IMP[15178420]	5
GO:0035473	lipase binding	molecular function	IPI[15178420]	3
GO:0006695	cholesterol biosynthetic process	biological process	IBA	3
GO:0031102	neuron projection regeneration	biological process	IBA	3
GO:0005576	extracellular region	cellular component	IDA[11577099]; TAS	31
GO:0033344	cholesterol efflux	biological process	IBA	6
GO:0006641	triglyceride metabolic process	biological process	IDA[11588264]; IMP[12417525\|14729863\|17142127]	6
GO:0050750	low-density lipoprotein particle receptor binding	molecular function	IPI[17326667]	5
GO:0034361	very-low-density lipoprotein particle	cellular component	IDA[15528295]	7
GO:0045723	positive regulation of fatty acid biosynthetic process	biological process	IDA[18635818]	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa03320	PPAR signaling pathway	3

Gene related interactors from protein-protein interactions data in PINA v2 (count: 2)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
APOA5	SMARCD1	No	--	--	21988832 , 21988832
APOA5	SORL1	No	--	--	17326667 , 17326667 , 17326667 , 17326667