Study Report
Study Information
Basic Info
| Reference |
Melroy-Greif, W. E.,2017 PMID: 28262088
|
| Citation |
Melroy-Greif, W. E., et al. (2017). "Genome-Wide Association Study of Post-Traumatic Stress Disorder in Two High-Risk Populations." Twin Res Hum Genet 20(3): 197-207. |
| Phenotype |
PTSD symptoms |
| Trauma |
Various |
| Study Design |
Cross-sectional study |
| Study Type |
Genome-wide association study |
| Sample Size |
254 samples |
| SNP/Marker Size |
258,441 SNPs |
| Predominant Ethnicity |
Caucasian, Mongloid |
| Population |
American |
| Gender |
MA cohort: 46.85% males, 53.15% females. AI cohort: 43.41% males, 56.59% females. |
| Age |
MA cohort: mean age=23.78, SD=3.71. AI cohort: mean age=31.84, SD=14.47. |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) |
| Sample Status |
For the MA cohort: subjects who were pregnant, nursing, or currently had a major medical or neurological disorder were excluded. |
| Controls Exposed |
NA |
| Replication Size |
258 samples |
| Result Summary |
A genome-wide association study (GWAS) with sum PTSD symptoms for trauma-exposed subjects was run in each cohort. Six highly correlated variants in olfactory receptor family 11 subfamily L member 1 (OR11L1) were suggestively associated with PTSD in the MA cohort. These associations remained suggestively significant after permutation testing. A signal in a nearby olfactory receptor on chromosome 1, olfactory receptor family 2 subfamily L member 13 (OR2L13), tagged by rs151319968, was nominally associated with PTSD in the AI sample. No variants were significantly associated after correction for multiple testing in a meta-analysis of the two cohorts. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 7)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
rs6681483
|
PTSD symptoms |
OR11L1 |
B=4.183, P-value=1.83E-06 |
This SNP was suggestively associated with PTSD. The OR11L1 h......
This SNP was suggestively associated with PTSD. The OR11L1 hits on chromosome 1 in the MA sample did not replicate in AI sample.
More...
|
Trend |
|
rs10888255
|
PTSD symptoms |
OR11L1 |
B=4.183, P-value=1.83E-06 |
This SNP was suggestively associated with PTSD. The OR11L1 h......
This SNP was suggestively associated with PTSD. The OR11L1 hits on chromosome 1 in the MA sample did not replicate in AI sample.
More...
|
Trend |
|
rs6667389
|
PTSD symptoms |
OR11L1 |
B=4.183, P-value=1.83E-06 |
This SNP was suggestively associated with PTSD. The OR11L1 h......
This SNP was suggestively associated with PTSD. The OR11L1 hits on chromosome 1 in the MA sample did not replicate in AI sample.
More...
|
Trend |
|
rs10888256
|
PTSD symptoms |
OR11L1 |
B=4.147, P-value=2.05E-06 |
This SNP was suggestively associated with PTSD. The OR11L1 h......
This SNP was suggestively associated with PTSD. The OR11L1 hits on chromosome 1 in the MA sample did not replicate in AI sample.
More...
|
Trend |
|
rs10888257
|
PTSD symptoms |
OR11L1 |
B=4.183, P-value=1.83E-06 |
This SNP was suggestively associated with PTSD. The OR11L1 h......
This SNP was suggestively associated with PTSD. The OR11L1 hits on chromosome 1 in the MA sample did not replicate in AI sample.
More...
|
Trend |
|
rs151319968
|
PTSD symptoms |
OR2L13 |
P-value<0.01 |
Rs151319968 was nominally associated with PTSD.
Rs151319968 was nominally associated with PTSD.
|
Trend |
|
rs4607924
|
PTSD symptoms |
OR11L1 |
B=4.147, P-value=2.05E-06 |
This SNP was suggestively associated with PTSD. The OR11L1 h......
This SNP was suggestively associated with PTSD. The OR11L1 hits on chromosome 1 in the MA sample did not replicate in AI sample.
More...
|
Trend |
