Meta-analysis Report
Basic Info
| Reference |
Li, L.,2016 PMID: 26986136
|
| Citation |
Li, L., et al. (2016). "The Association Between Genetic Variants in the Dopaminergic System and Posttraumatic Stress Disorder: A Meta-Analysis." Medicine (Baltimore) 95(11): e3074. |
| Objective |
To perform a systematic literature search and conduct meta-analysis to examine whether genetic variants in the dopaminergic system is associated with PTSD. |
| Study Type |
Candidate gene association study |
| Extract Database |
PubMed, Cochrane Library, Embase, Google Scholar,HuGE |
| Time Range |
Before May 31, 2015 |
Detail Info
| Samples |
For DRD2: 597 cases, 1155 controls. For SLC6A3: 213 cases, 387 controls. For COMT: 626 cases, 418 controls. For DBH: 202 cases, 192 control. |
| Statistic Method |
In all meta-analyses, we used random-effects models to calculate OR and the corresponding 95% CI. Between-study heterogeneity and publication bias was assessed using I2 and a funnel plot and Egger test, respectively. Findings from meta- analyses were confirmed using random-effects meta-analyses under the framework of generalized linear model (GLM). |
| Basic Result |
We found that rs1800497 in DRD2 and the VNTR in SLC6A3 showed significant association with PTSD. |
Genetic result reported by this study
