PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

SNP Report

Basic Info

Name	rs71534169 dbSNP Ensembl
Location	7:154801156 - 154801156(+)
Variant Seq	G
Ancestral Allele	T
Ref Seq	T
Minor Allele Frequence	0.0191693
Annotation	downstream_gene_variant; upstream_gene_variant; intron_variant; non_coding_transcript_variant
Variant Effect	downstream_gene_variant(ENST00000481593, ENST00000634859); upstream_gene_variant(ENST00000493268, ENST00000634717); intron_variant(ENST00000332007, ENST00000634466, ENST00000427557, ENST00000635128, ENST00000634779, ENST00000634541, ENST00000471100, ENST00000377770, ENST00000634521, ENST00000404039); non_coding_transcript_variant(ENST00000471100, ENST00000634521)
SIFT Annotation	tolerated
SIFT Variant Effect	tolerated(ENST00000404039, ENST00000634466, ENST00000634541, ENST00000427557, ENST00000332007, ENST00000634779, ENST00000377770, ENST00000635128)
PolyPhen Annotation	probably_damaging; possibly_damaging
PolyPhen Variant Effect	probably_damaging(ENST00000634466, ENST00000427557, ENST00000332007, ENST00000634779); possibly_damaging(ENST00000404039, ENST00000634541, ENST00000377770, ENST00000635128)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	TF binding region
Chromatin State	Weak transcription
No. of Marker's Association Results	1 (Positive: 0; Negative: 0; Trend: 1)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Wolf, E. J.,2014	Dissociative symptom severity	Linear regression: B=1.63, SE=0.35, P-value=3.79E-06, R Linear regression: B=1.63, SE=0.35, P-value=3.79E-06, R²=0.04. Controlling for PTSD severity: P-value=3.96E-05. SNP and sex interaction: B=-2.34, P-value=0.002. Stratifying by sex, among women: B=3.26, P-value=6.96E?07, among men: B=0.93, P-value=.03. More...	A second SNP in the suggestive range was rs71534169. The eff...... A second SNP in the suggestive range was rs71534169. The effect of the SNP remained significant after controlling for PTSD severity, and there was a significant SNP and sex interaction. Stratifying by sex showed the effect to be stronger among women than men. More...	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
DPP6	dipeptidyl-peptidase 6	7q36.2	1(0/0/1)

SNPs in LD with rs71534169 (count: 0)

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
LRRC37A4P	No	Adipose Subcutaneous	cis	GTEx