Gene Report

Basic Info

Approved Symbol	ADCYAP1
Symbol Alias	PACAP
Approved Name	adenylate cyclase activating polypeptide 1 (pituitary)
Name Alias	prepro-PACAP
Location	18p11
Position	chr18:904943-912172, 1
External Links	HGNC: 241 Entrez Gene: 116 Ensembl: ENSG00000141433 UCSC: uc010dkh.4
No. of Association Results	6 (Positive: 0; Negative: 6; trend: 0)
Annotation Type	Literature-origin

Gene related association results

Normal genetic study related association results (count: 6)

Reference	Phenotype	Marker	Gene's Category
Chang, S. C.,2012	Chronic PTSD	rs2267735	Non-significant
Chang, S. C.,2012	Current PTSD	rs2267735	Non-significant
Chang, S. C.,2012	PTSD	rs2267735	Non-significant
Chang, S. C.,2012	PTSD symptom severity	rs2267735	Non-significant
Chang, S. C.,2012	PTSD symptom subscale scores	rs2267735	Non-significant
Chang, S. C.,2012	Total number of PTSD symptoms	rs2267735	Non-significant

Gene functional annotation

Gene related GO terms (count: 54)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0060253	negative regulation of glial cell proliferation	biological process	IEA	1
GO:0008284	positive regulation of cell proliferation	biological process	IEA	14
GO:0007218	neuropeptide signaling pathway	biological process	IDA[23800469]	4
GO:0005515	protein binding	molecular function	IPI[25451228]	169
GO:0005622	intracellular	cellular component	IMP[23800469]	15
GO:0001541	ovarian follicle development	biological process	IEA	2
GO:0016521	pituitary adenylate cyclase activating polypeptide activity	molecular function	IDA[9603988]	1
GO:0042594	response to starvation	biological process	IEA	2
GO:0005615	extracellular space	cellular component	IEA	27
GO:0010656	negative regulation of muscle cell apoptotic process	biological process	IEA	2
GO:0007267	cell-cell signaling	biological process	TAS[2302217]	10
GO:0002878	negative regulation of acute inflammatory response to non-antigenic stimulus	biological process	IEA	1
GO:0043547	positive regulation of GTPase activity	biological process	IDA[23800469]	13
GO:0001662	behavioral fear response	biological process	IEA	7
GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	biological process	IDA[24696163]	1
GO:0005184	neuropeptide hormone activity	molecular function	IDA[23800469]	4
GO:0005057	receptor signaling protein activity	molecular function	IEA	1
GO:0070445	regulation of oligodendrocyte progenitor proliferation	biological process	IEA	1
GO:0021983	pituitary gland development	biological process	IEA	1
GO:0045471	response to ethanol	biological process	IEA	18
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	IEA	4
GO:0001821	histamine secretion	biological process	IEA	1
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	11
GO:0060078	regulation of postsynaptic membrane potential	biological process	IEA	1
GO:0010976	positive regulation of neuron projection development	biological process	IEA	4
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	TAS	4
GO:0031175	neuron projection development	biological process	IDA[23800469]	8
GO:0032755	positive regulation of interleukin-6 production	biological process	IEA	5
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IEA	7
GO:0043267	negative regulation of potassium ion transport	biological process	IEA	4
GO:0071385	cellular response to glucocorticoid stimulus	biological process	IEA	3
GO:0043195	terminal bouton	cellular component	IEA	7
GO:0019233	sensory perception of pain	biological process	IEA	9
GO:0032880	regulation of protein localization	biological process	IDA[9603988]	2
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	biological process	IDA[11175907]	3
GO:0051428	peptide hormone receptor binding	molecular function	IDA[11175907]; IPI[17470806]	1
GO:0007190	activation of adenylate cyclase activity	biological process	TAS	6
GO:0060124	positive regulation of growth hormone secretion	biological process	IEA	3
GO:0005102	receptor binding	molecular function	IPI[7680413]	13
GO:0046034	ATP metabolic process	biological process	IEA	1
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological process	IDA[9603988]	2
GO:0090274	positive regulation of somatostatin secretion	biological process	IEA	1
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IDA[23800469]	10
GO:0045909	positive regulation of vasodilation	biological process	IEA	5
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[23800469]	25
GO:0019933	cAMP-mediated signaling	biological process	IMP[23800469]	4
GO:0031858	pituitary adenylate cyclase-activating polypeptide receptor binding	molecular function	IEA	1
GO:0005576	extracellular region	cellular component	TAS	31
GO:0007565	female pregnancy	biological process	TAS[10698193]	9
GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus	biological process	IEA	1
GO:0005829	cytosol	cellular component	IEA	78
GO:0045860	positive regulation of protein kinase activity	biological process	IDA[23800469]	4
GO:0045786	negative regulation of cell cycle	biological process	IEA	1
GO:0034260	negative regulation of GTPase activity	biological process	IEA	2

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 7)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
ADCYAP1	SCTR	No	--	--	1335692 , 1335692 , 1335692
ADCYAP1	SHH	No	--	--	12417650
ADCYAP1	VIPR1	Yes	--	--	12429744
ADCYAP1	CASP2	No	--	--	11972030
ADCYAP1	CPAMD8	No	--	--	1335692
ADCYAP1	ADCYAP1R1	Yes	--	--	10583729
ADCYAP1	VIPR2	No	--	--	8146174